Today, organ transplants no longer remain a desperate situation as was decades ago. However, among the varieties of the organ transplants, lung transplant patients have a higher rate of the organ transplant failures. In lieu of this, the heart, kidney and the liver transplant patients face a comparatively lower risk of organ transplant failures. The primary cause of the organ transplant failure is the inflammation which results out in the donor from the newly transplanted lung.
The current research involves the best brains from the Washington University School of Medicine in St. Louis and North Western University Feinberg School of Medicine in Chicago. These flock of researchers has unveiled the precise cells which flow into the donor and infect the lung immediately after the transplant procedure. It results in the dysfunction and is one of the leading factors of the early death after the lung transplantation. It results in the organ rejection which may terminate in fatalities few months or years later.
Daniel Kreisel says, “More than 50 percent of lung transplant patients experience some lung damage after a transplant. Eliminating this problem would increase the success of lung transplants.” Daniel Kreisel is the MD, Ph.D., and a surgical director of the lung transplantation at Washington University and Barnes-Jewish Hospital.
The current research study marks its presence in The Journal of Clinical Investigation. The paper was published online on May 21, 2018.
According to the Kreisel, the early lung damage occurs within the first seventy-two hours from the lung transplantation surgery. The moment the lung is removed from the donor, it undergoes flushing with the help of a cold preservation liquid. Later the treated lung is placed on the ice where it is deprived of the blood and oxygen supply. The lung damage proceeds after the surgical implantation of the lung and once the blood from the recipient’s body enters the lung for the first time. Later, the white blood cells of the recipient make a way to the transplanted lungs and give rise to the inflammation. It is this inflammation caused by the recipient’s white blood cells that damage the organ tissue. This results in the organ transplant failure, and hence, the person has stayed on a ventilator for an extended period. Alternatively, your medical practitioners may monitor your lung recovery with the help of the lung bypass machine.